Adsorption of human salivary mucins to hydroxyapatite

Adsorption of human salivary mucins to hydroxyapatite

The interactions between low (MG2) and high (MG1) molecular-weight human submandibular-sublingual mucin and hydroxyapatite (OHAp) were compared using a quantitative assay. Data obtained appeared to empirically fit the Langmuir adsorption isotherm. Apparent affinity constants derived from this isothe...

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Veröffentlicht in:Archives of oral biology 1985, Vol.30 (5), p.423-427
Hauptverfasser: Tabak, L.A., Levine, M.J., Jain, N.K., Bryan, Amy R., Cohen, R.E., Monte, Laura D., Zawacki, S., Nancollas, G.H., Slomiany, Amalia, Slomiany, B.L.
Format: Artikel
Sprache:eng
Schlagworte:
Adsorption
Dentistry
Durapatite
Glycolipids
Humans
Hydroxyapatites
Molecular Weight
Mucins
Phosphoproteins
Salivary Proteins and Peptides
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Beschreibung
Zusammenfassung:The interactions between low (MG2) and high (MG1) molecular-weight human submandibular-sublingual mucin and hydroxyapatite (OHAp) were compared using a quantitative assay. Data obtained appeared to empirically fit the Langmuir adsorption isotherm. Apparent affinity constants derived from this isotherm indicated that MG1 had a greater affinity for OHAp than did MG2. Inhibition studies revealed that salivary glycolipids inhibited the interaction of MG1 and OHAp without influencing MG2 adsorption. In contrast, MG2 adsorption to OHAp was markedly inhibited by cysteine-containing salivary phosphoprotein fractions. Collectively, the data indicate MG1 and MG2 differ in their interaction with OHAp.
ISSN:0003-9969
1879-1506
DOI:10.1016/0003-9969(85)90070-6