Carbonic Anhydrase Activators. VII. Isozyme II Activation by Bisazolyl-methanes, -ethanes and Related Azoles

A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1993/12/15, Vol.16(12), pp.1236-1239
Hauptverfasser:	SUPURAN, Claudiu T., BALABAN, Alexandru T., CABILDO, Pilar, CLARAMUNT, Rosa Maria, LAVANDERA, Jose Luis, ELGUERO, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	azole Azoles - pharmacology Biological and medical sciences bisazolyl-methane/ethane carbonic anhydrase Carbonic Anhydrases - metabolism Enzyme Activation Isoenzymes - metabolism isozyme II Kinetics Medical sciences Miscellaneous Pharmacology. Drug treatments pKa
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Beschreibung
Zusammenfassung:	A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.16.1236