Facile Two-Step Synthesis of Porous Antigen-Loaded Degradable Polyelectrolyte Microspheres

Pore medicine: Porous antigen‐loaded degradable polyelectrolyte microspheres are produced in a straightforward way providing high encapsulation efficiencies and efficient internalization by antigen‐presenting cells. This system could find application as multilayer capsules in gene and drug delivery...

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Veröffentlicht in:	Angewandte Chemie International Edition 2010-11, Vol.49 (46), p.8620-8624
Hauptverfasser:	Dierendonck, Marijke, De Koker, Stefaan, Cuvelier, Claude, Grooten, Johan, Vervaet, Chris, Remon, Jean-Paul, De Geest, Bruno G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antigens Antigens - administration & dosage Bone Marrow Cells - metabolism Calcium Carbonate - chemistry Cholera Toxin - administration & dosage Dextran Sulfate - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry drug delivery Electrolytes - chemistry Mice microporous materials Microscopy, Confocal Microspheres Nanoparticles - chemistry nanotechnology Ovalbumin - administration & dosage Peptide Fragments - administration & dosage polymers Porosity
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Beschreibung
Zusammenfassung:	Pore medicine: Porous antigen‐loaded degradable polyelectrolyte microspheres are produced in a straightforward way providing high encapsulation efficiencies and efficient internalization by antigen‐presenting cells. This system could find application as multilayer capsules in gene and drug delivery and for enzymatic microreactors.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201001046