Ruthenium-Catalyzed Tertiary Amine Formation from Nitroarenes and Alcohols

Ruthenium-Catalyzed Tertiary Amine Formation from Nitroarenes and Alcohols

A highly selective ruthenium-catalyzed C−N bond formation was developed by using the hydrogen-borrowing strategy. Various tertiary amines were obtained efficiently from nitroarenes and primary alcohols. The reaction tolerates a wide range of functionalities. A tentative mechanism was proposed for th...

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Veröffentlicht in:Organic letters 2010-11, Vol.12 (21), p.4888-4891
Hauptverfasser: Feng, Chao, Liu, Yong, Peng, Shengming, Shuai, Qi, Deng, Guojun, Li, Chao-Jun
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemistry
Amination
Amines - chemical synthesis
Catalysis
Hydrogen - chemistry
Molecular Structure
Nitrogen Compounds - chemistry
Ruthenium - chemistry
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Zusammenfassung:A highly selective ruthenium-catalyzed C−N bond formation was developed by using the hydrogen-borrowing strategy. Various tertiary amines were obtained efficiently from nitroarenes and primary alcohols. The reaction tolerates a wide range of functionalities. A tentative mechanism was proposed for this direct amination reaction of alcohols with nitroarenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1020527