Cholinergic modulation of the swimmeret motor system in crayfish
G. Braun and B. Mulloney Section of Neurobiology, Physiology and Behavior, University of California, Davis 95616. 1. The muscarinic agonist pilocarpine induced the swimmeret motor pattern in resting isolated preparations of the crayfish abdominal nerve cord and modulated the burst frequency in a dos...
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Veröffentlicht in: | Journal of neurophysiology 1993-12, Vol.70 (6), p.2391-2398 |
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Sprache: | eng |
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Zusammenfassung: | G. Braun and B. Mulloney
Section of Neurobiology, Physiology and Behavior, University of California, Davis 95616.
1. The muscarinic agonist pilocarpine induced the swimmeret motor pattern
in resting isolated preparations of the crayfish abdominal nerve cord and
modulated the burst frequency in a dose-dependent manner. 2. Nicotine did
not elicit rhythmic activity in resting isolated preparations but increased
the burst frequency in active preparations. Nicotine produced higher burst
frequencies than pilocarpine. 3. The acetylcholine (ACh) analogue carbachol
combined the effects of pilocarpine and nicotine. It activated isolated
resting preparations and increased the burst frequency as effectively as
nicotine. The ACh-esterase inhibitor eserine also increased the burst
frequency in active preparations. 4. Neither muscarinic nor nicotinic
antagonists disrupted the proctolin-induced motor pattern, suggesting that
proctolin and cholinergic agonists affect two different pathways for the
activation of the swimmeret system. 5. We conclude that cholinergic
interneurons participate in initiation of the swimmeret motor pattern and
can modulate its burst frequency. |
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ISSN: | 0022-3077 1522-1598 |
DOI: | 10.1152/jn.1993.70.6.2391 |