Site-specific recombinases: tools for genome engineering

Site-specific recombinases: tools for genome engineering

Site-specific recombinases from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their...

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Veröffentlicht in:Trends in genetics 1993-12, Vol.9 (12), p.413-421
Hauptverfasser: Kilby, Nigel J., Snaith, Michael R., Murray, James A.H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
bacteriophages
Base Sequence
deoxyribonucleases
DNA Nucleotidyltransferases - metabolism
Genetic Engineering
genetic recombination
Genome
literature reviews
Molecular Sequence Data
nucleases
plasmids
Saccharomyces cerevisiae
Saccharomycetales
site specific recombination
Substrate Specificity
zygosaccharomyces rouxii
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Beschreibung
Zusammenfassung:Site-specific recombinases from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.
ISSN:0168-9525
DOI:10.1016/0168-9525(93)90104-P