Graphical Approach for Determining Whether Absorption and Elimination Rate Constants are Equal in the One-Compartment Open Model with First-Order Processes

Graphical Approach for Determining Whether Absorption and Elimination Rate Constants are Equal in the One-Compartment Open Model with First-Order Processes

An equation was developed which enables blood level data to be utilized for determining whether or not the first-order absorption and elimination rate constants are equal in the one-compartment open model. This equation was tested using simulated data with excellent results.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of pharmaceutical sciences 1985-05, Vol.74 (5), p.582-584
1. Verfasser: Macheras, Panayotis E.
Format: Artikel
Sprache:eng
Schlagworte:
Absorption
Biological and medical sciences
General pharmacology
Half-Life
Humans
Kinetics
Medical sciences
Models, Biological
Pharmaceutical Preparations - blood
Pharmaceutical Preparations - metabolism
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
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Zusammenfassung:An equation was developed which enables blood level data to be utilized for determining whether or not the first-order absorption and elimination rate constants are equal in the one-compartment open model. This equation was tested using simulated data with excellent results.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600740521