The impact of new treatment options for advanced colorectal cancer on routine care: results of a retrospective analysis of 206 consecutive patients treated in a community-based oncology group practice in Germany

KÖPPLER H., HEYMANNS J., THOMALLA J., KLEBOTH K. & WEIDE R. (2010) European Journal of Cancer Care19, 795–802 The impact of new treatment options for advanced colorectal cancer on routine care: results of a retrospective analysis of 206 consecutive patients treated in a community‐based oncology group practice in Germany Due to necessary selection criteria, the results obtained in clinical trials may not reflect the actual impact of current treatment options for unselected general populations. We analysed the treatment modalities and the outcome in 206 consecutive patients with advanced colorectal cancer who started treatment between 1/1999 and 11/2004. The median age of this cohort was 66 years (range 30–87) and 39 patients (19%) were ≥75 years old. First‐line treatment consisted of low‐dose bolus 5‐fluorouracil and folinic acid regimens in 68 patients (33%), weekly 24‐h 5‐fluorouracil infusion and folinic acid in 36 patients (17%), weekly 24‐h 5‐fluorouracil infusion plus oxaliplatin or irinotecan in 60 patients (29%), capecitabine regimens in 22 patients (11%), monotherapy with oxaliplatin or irinotecan in six patients (3%) and other regimens in 14 patients (7%). A total of 166 patients (81%) received a second‐line treatment and third‐line chemotherapy was given to 122/206 patients (59%). With a minimum follow‐up of 18 months, the median survival of the cohort is 21 months (range 1–85) and 17 months (range 3–57) for patients ≥75 years. We conclude that the increased survival seen in prospective studies can be transferred to routine care for unselected patients with advanced colorectal cancer.