BDNF stimulates Ca2+ oscillation frequency in melanotrope cells of Xenopus laevis : Contribution of IP3-receptor-mediated release of intracellular Ca2+ to gene expression

Research highlights ► BDNF mobilizes Ca2+ from IP3 -sensitive intracellular Ca2+ stores in Xenopus laevis melanotrope cell. ► Mobilization of intracellular Ca2+ leads to stimulated Ca2+ oscillations. ► Stimulated Ca2+ oscillation frequency may selectively stimulate expression of the BDNF gene.

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Veröffentlicht in:	General and comparative endocrinology 2010-11, Vol.169 (2), p.123-129
Hauptverfasser:	Kuribara, Miyuki, Eijsink, Vivian D, Roubos, Eric W, Jenks, Bruce G, Scheenen, Wim J.J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - pharmacology Calcium - metabolism Cells, Cultured Endocrinology & Metabolism Inositol 1,4,5-Trisphosphate Receptors - metabolism Melanotrophs - cytology Melanotrophs - drug effects Melanotrophs - metabolism Neuroendocrine Cells - drug effects Neuroendocrine Cells - metabolism Reverse Transcriptase Polymerase Chain Reaction Xenopus laevis
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Beschreibung
Zusammenfassung:	Research highlights ► BDNF mobilizes Ca2+ from IP3 -sensitive intracellular Ca2+ stores in Xenopus laevis melanotrope cell. ► Mobilization of intracellular Ca2+ leads to stimulated Ca2+ oscillations. ► Stimulated Ca2+ oscillation frequency may selectively stimulate expression of the BDNF gene.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2010.08.010