Advanced antisense therapies for postexposure protection against lethal filovirus infections

Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2010-09, Vol.16 (9), p.991-994
Hauptverfasser:	Iversen, Patrick L, Bavari, Sina, Warren, Travis K, Warfield, Kelly L, Wells, Jay, Swenson, Dana L, Donner, Kelly S, Van Tongeren, Sean A, Garza, Nicole L, Dong, Lian, Mourich, Dan V, Crumley, Stacy, Nichols, Donald K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61/51/391/1914 692/699/255/2514 Animals Antisense drugs Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Cynomolgus Drug dosages Drug therapy Ebola virus Ebolavirus - isolation & purification Filoviridae Infections - genetics Filoviridae Infections - immunology Filoviridae Infections - mortality Filoviridae Infections - prevention & control Filovirus Health aspects Hemorrhagic Fever, Ebola - genetics Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - prevention & control Humans Infections Infectious Diseases Lakes Macaca mulatta Macaca mulatta - immunology Marburg virus Marburg virus disease Marburg Virus Disease - genetics Marburg Virus Disease - immunology Marburg Virus Disease - prevention & control Marburgvirus - isolation & purification Metabolic Diseases Molecular Medicine Monkeys & apes Neurosciences Primates Safety Vaccines Vaccines, Synthetic - therapeutic use Viral Vaccines - therapeutic use Virus diseases Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30-60 min after infection, protects >60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection. PMOplus may be useful for treating these and other highly pathogenic viruses in humans.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.2202