A ceramic-based anticancer drug delivery system to treat breast cancer
Drug delivery systems offer the advantage of sustained targeted release with minimal side effect. In the present study, the therapeutic efficacy of a porous silica–calcium phosphate nanocomposite (SCPC) as a new delivery system for 5-Fluorouracil (5-FU) was evaluated in vitro and in vivo. In vitro s...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2010-09, Vol.21 (9), p.2701-2710 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | El-Ghannam, Ahmed Ricci, Krista Malkawi, Ahmed Jahed, Kiarash Vedantham, Kumar Wyan, Heather Allen, Lauren D. Dréau, Didier |
| description | Drug delivery systems offer the advantage of sustained targeted release with minimal side effect. In the present study, the therapeutic efficacy of a porous silica–calcium phosphate nanocomposite (SCPC) as a new delivery system for 5-Fluorouracil (5-FU) was evaluated in vitro and in vivo. In vitro studies showed that two formulations; SCPC50/5-FU and SCPC75/5-FU hybrids were very cytotoxic for 4T1 mammary tumor cells. In contrast, control SCPCs without drug did not show any measurable toxic effect. Release kinetics studies showed that SCPC75/5-FU hybrid provided a burst release of 5-FU in the first 24 h followed by a sustained release of a therapeutic dose (30.7 μg/day) of the drug for up to 32 days. Moreover, subcutaneous implantation of SCPC75/5-FU hybrid disk in an immunocompetent murine model of breast cancer stopped 4T1 tumor growth. Blood analyses showed comparable concentrations of Ca, P and Si in animals implanted with or without SCPC75 disks. These results strongly suggest that SCPC/5-FU hybrids can provide an effective treatment for solid tumors with minimal side effects. |
| doi_str_mv | 10.1007/s10856-010-4121-6 |
| format | Article |
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In the present study, the therapeutic efficacy of a porous silica–calcium phosphate nanocomposite (SCPC) as a new delivery system for 5-Fluorouracil (5-FU) was evaluated in vitro and in vivo. In vitro studies showed that two formulations; SCPC50/5-FU and SCPC75/5-FU hybrids were very cytotoxic for 4T1 mammary tumor cells. In contrast, control SCPCs without drug did not show any measurable toxic effect. Release kinetics studies showed that SCPC75/5-FU hybrid provided a burst release of 5-FU in the first 24 h followed by a sustained release of a therapeutic dose (30.7 μg/day) of the drug for up to 32 days. Moreover, subcutaneous implantation of SCPC75/5-FU hybrid disk in an immunocompetent murine model of breast cancer stopped 4T1 tumor growth. Blood analyses showed comparable concentrations of Ca, P and Si in animals implanted with or without SCPC75 disks. These results strongly suggest that SCPC/5-FU hybrids can provide an effective treatment for solid tumors with minimal side effects.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-010-4121-6</identifier><identifier>PMID: 20644983</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - administration & dosage ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Breast cancer ; Breast Neoplasms - drug therapy ; Ceramics ; Chemistry and Materials Science ; Chemotherapy ; Composites ; Drug delivery systems ; Female ; Glass ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Materials Science ; Medical sciences ; Nanomaterials ; Natural Materials ; Pharmacology. Drug treatments ; Polymer Sciences ; Regenerative Medicine/Tissue Engineering ; Surfaces and Interfaces ; Thin Films ; Tumors</subject><ispartof>Journal of materials science. 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Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Drug delivery systems offer the advantage of sustained targeted release with minimal side effect. In the present study, the therapeutic efficacy of a porous silica–calcium phosphate nanocomposite (SCPC) as a new delivery system for 5-Fluorouracil (5-FU) was evaluated in vitro and in vivo. In vitro studies showed that two formulations; SCPC50/5-FU and SCPC75/5-FU hybrids were very cytotoxic for 4T1 mammary tumor cells. In contrast, control SCPCs without drug did not show any measurable toxic effect. Release kinetics studies showed that SCPC75/5-FU hybrid provided a burst release of 5-FU in the first 24 h followed by a sustained release of a therapeutic dose (30.7 μg/day) of the drug for up to 32 days. Moreover, subcutaneous implantation of SCPC75/5-FU hybrid disk in an immunocompetent murine model of breast cancer stopped 4T1 tumor growth. Blood analyses showed comparable concentrations of Ca, P and Si in animals implanted with or without SCPC75 disks. These results strongly suggest that SCPC/5-FU hybrids can provide an effective treatment for solid tumors with minimal side effects.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Chemotherapy</subject><subject>Composites</subject><subject>Drug delivery systems</subject><subject>Female</subject><subject>Glass</subject><subject>Gynecology. Andrology. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Ghannam, Ahmed</au><au>Ricci, Krista</au><au>Malkawi, Ahmed</au><au>Jahed, Kiarash</au><au>Vedantham, Kumar</au><au>Wyan, Heather</au><au>Allen, Lauren D.</au><au>Dréau, Didier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A ceramic-based anticancer drug delivery system to treat breast cancer</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>21</volume><issue>9</issue><spage>2701</spage><epage>2710</epage><pages>2701-2710</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Drug delivery systems offer the advantage of sustained targeted release with minimal side effect. In the present study, the therapeutic efficacy of a porous silica–calcium phosphate nanocomposite (SCPC) as a new delivery system for 5-Fluorouracil (5-FU) was evaluated in vitro and in vivo. In vitro studies showed that two formulations; SCPC50/5-FU and SCPC75/5-FU hybrids were very cytotoxic for 4T1 mammary tumor cells. In contrast, control SCPCs without drug did not show any measurable toxic effect. Release kinetics studies showed that SCPC75/5-FU hybrid provided a burst release of 5-FU in the first 24 h followed by a sustained release of a therapeutic dose (30.7 μg/day) of the drug for up to 32 days. Moreover, subcutaneous implantation of SCPC75/5-FU hybrid disk in an immunocompetent murine model of breast cancer stopped 4T1 tumor growth. Blood analyses showed comparable concentrations of Ca, P and Si in animals implanted with or without SCPC75 disks. These results strongly suggest that SCPC/5-FU hybrids can provide an effective treatment for solid tumors with minimal side effects.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20644983</pmid><doi>10.1007/s10856-010-4121-6</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Antineoplastic agents Antineoplastic Agents - administration & dosage Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Breast cancer Breast Neoplasms - drug therapy Ceramics Chemistry and Materials Science Chemotherapy Composites Drug delivery systems Female Glass Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Materials Science Medical sciences Nanomaterials Natural Materials Pharmacology. Drug treatments Polymer Sciences Regenerative Medicine/Tissue Engineering Surfaces and Interfaces Thin Films Tumors |
| title | A ceramic-based anticancer drug delivery system to treat breast cancer |
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