Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves’ ophthalmopathy: evidence that oxidative stress has a role in this disorder

Purpose We investigated the oxidative stress in orbital fibroadipose tissues and cultured orbital fibroblasts from patients with Graves’ ophthalmopathy (GO). Methods The content of 8-hydroxy 2′-deoxyguanosine (8-OHdG), an important biomarker of oxidative DNA damage, was measured in orbital fibroadip...

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Veröffentlicht in:	Eye (London) 2010-09, Vol.24 (9), p.1520-1525
Hauptverfasser:	Tsai, C-C, Wu, S-B, Cheng, C-Y, Kao, S-C, Kau, H-C, Chiou, S-H, Hsu, W-M, Wei, Y-H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1427 631/443/319 692/698/690 Adipose Tissue - metabolism Biological and medical sciences Biomarkers - metabolism Cells, Cultured - metabolism Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA Damage - physiology Endocrinopathies Fibroblasts - metabolism Fibroblasts - pathology Graves Ophthalmopathy - metabolism Graves Ophthalmopathy - pathology Humans Hydrogen Peroxide - metabolism Laboratory Medicine laboratory-study Lipid Peroxidation - physiology Malondialdehyde - metabolism Medical sciences Medicine Medicine & Public Health Miscellaneous Non tumoral diseases. Target tissue resistance. Benign neoplasms Ophthalmology Orbit - metabolism Orbit - pathology Oxidative Stress Pharmaceutical Sciences/Technology Reactive Oxygen Species - metabolism Superoxides - metabolism Surgery Surgical Oncology Thyroid. Thyroid axis (diseases)
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