Click Chemistry on Azidoproline: High-Affinity Dual Antagonist for HIV-1 Envelope Glycoprotein gp120
High affinity dual antagonist: The envelope glycoprotein gp120 of HIV‐1 mediates the first steps of viral entry into the host cell. An azidoproline‐based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell‐surface receptor and 17b (an antibody surrogate of the CCR5 co‐receptor...
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| Veröffentlicht in: | ChemMedChem 2006-01, Vol.1 (1), p.54-57 |
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| creator | Gopi, Hosahudya N. Tirupula, Kalyan C. Baxter, Sabine Ajith, Sandya Chaiken, Irwin M. |
| description | High affinity dual antagonist: The envelope glycoprotein gp120 of HIV‐1 mediates the first steps of viral entry into the host cell. An azidoproline‐based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell‐surface receptor and 17b (an antibody surrogate of the CCR5 co‐receptor). It represents a potentially effective approach in preventing HIV infection. |
| doi_str_mv | 10.1002/cmdc.200500037 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | ChemMedChem, 2006-01, Vol.1 (1), p.54-57 |
| issn | 1860-7179 1860-7187 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology antiviral agents Azides - chemistry Azides - pharmacology CD4 Antigens - metabolism click chemistry HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - drug effects HIV Envelope Protein gp120 - metabolism HIV-1 Human immunodeficiency virus 1 inhibitors Molecular Sequence Data Proline - analogs & derivatives Proline - chemistry Proline - pharmacology Protein Binding Structure-Activity Relationship viruses |
| title | Click Chemistry on Azidoproline: High-Affinity Dual Antagonist for HIV-1 Envelope Glycoprotein gp120 |
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