Click Chemistry on Azidoproline: High-Affinity Dual Antagonist for HIV-1 Envelope Glycoprotein gp120

High affinity dual antagonist: The envelope glycoprotein gp120 of HIV‐1 mediates the first steps of viral entry into the host cell. An azidoproline‐based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell‐surface receptor and 17b (an antibody surrogate of the CCR5 co‐receptor...

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Veröffentlicht in:	ChemMedChem 2006-01, Vol.1 (1), p.54-57
Hauptverfasser:	Gopi, Hosahudya N., Tirupula, Kalyan C., Baxter, Sabine, Ajith, Sandya, Chaiken, Irwin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology antiviral agents Azides - chemistry Azides - pharmacology CD4 Antigens - metabolism click chemistry HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - drug effects HIV Envelope Protein gp120 - metabolism HIV-1 Human immunodeficiency virus 1 inhibitors Molecular Sequence Data Proline - analogs & derivatives Proline - chemistry Proline - pharmacology Protein Binding Structure-Activity Relationship viruses
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Beschreibung
Zusammenfassung:	High affinity dual antagonist: The envelope glycoprotein gp120 of HIV‐1 mediates the first steps of viral entry into the host cell. An azidoproline‐based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell‐surface receptor and 17b (an antibody surrogate of the CCR5 co‐receptor). It represents a potentially effective approach in preventing HIV infection.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.200500037