Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives

Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the hig...

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Veröffentlicht in:Biology bulletin of the Russian Academy of Sciences 2010-08, Vol.37 (4), p.339-345
Hauptverfasser: Alekseeva, T. P, Rakhmetova, A. A, Bogoslovskaya, O. A, Olkhovskaya, I. P, Levov, A. N, Il'ina, A. V, Varlamov, V. P, Baitukalov, T. A, Glushchenko, N. N
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Cell Biology
chitosan
Developmental Biology
Ecology
Life Sciences
Wound healing
Zoology
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Zusammenfassung:Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359010040023