Ageing of the spermatogenesis system

Ageing of the spermatogenesis system

This review summarizes the data characterizing the effect of ageing on the development of male germ cells and their hereditary structures. We have studied causes of spermatogenesis reduction at late stages of ontogenesis. We have focused on age-specific changes of the structural—functional integrity...

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Veröffentlicht in:Biology bulletin of the Russian Academy of Sciences 2010-02, Vol.37 (1), p.10-17
Hauptverfasser: Zahidov, S. T., Hohlov, A. N., Malolina, E. A., Kulibin, A. Yu, Marshak, T. L.
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Biochemistry
Biomedical and Life Sciences
Cell Biology
Data processing
Ecology
Germ cells
Life Sciences
Microenvironments
Spermatogenesis
Zoology
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Beschreibung
Zusammenfassung:This review summarizes the data characterizing the effect of ageing on the development of male germ cells and their hereditary structures. We have studied causes of spermatogenesis reduction at late stages of ontogenesis. We have focused on age-specific changes of the structural—functional integrity of stem spermatogonial cells and their microenvironment (niche). We also examined several unique and specific features of the spermatogenic system in senescence-accelerated mutant mice (SAM), with accelerated ageing.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359010010024