THE EFFECT OF MOLSIDOMINE ON INTRAMYOCARDIAL PRESSURE AND REGIONAL MYOCARDIAL BLOOD FLOW IN THE CANINE ISCHEMIC MYOCARDIUM

Molsidomine was administered intraduodenally to anesthetized dogs which were instrumented for measurements of aortic and left ventricular (LV) pressures, coronary perfusion pressure, intramyocardial pressure in the subendocardium, and subendocardial and subepicardial myocardial blood flow in the isc...

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Veröffentlicht in:	JAPANESE CIRCULATION JOURNAL 1985/05/20, Vol.49(5), pp.507-515
Hauptverfasser:	KINOSHITA, MASAHIKO, MASHIRO, IWAO, MITSUNAMI, KENICHI, FUKUHARA, TAKEHISA, MOTOMURA, MASAKAZU, BITO, KEIZO, KAWAKITA, SEIICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Coronary Circulation - drug effects Coronary Disease - physiopathology Dogs Heart - drug effects Intramyocardial pressure Kinetics Medical sciences Molsidomine Myocardial ischemia Oxadiazoles - pharmacology Pharmacology. Drug treatments Regional Blood Flow - drug effects Regional myocardial blood flow Sydnones - metabolism Sydnones - pharmacology
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Zusammenfassung:	Molsidomine was administered intraduodenally to anesthetized dogs which were instrumented for measurements of aortic and left ventricular (LV) pressures, coronary perfusion pressure, intramyocardial pressure in the subendocardium, and subendocardial and subepicardial myocardial blood flow in the ischemic and non-ischemic regions. The dogs were divided into two groups: group M (n=9) was administered molsidomine (0.2 mg/kg), group S (n=10), saline only. Maximum LV systolic pressure decline was 20% in group M and 3% in group S (p
ISSN:	0047-1828 1347-4839
DOI:	10.1253/jcj.49.507