Apomorphine and amphetamine produce differential effects on the speed and success of reaction time responding in the rat

Apomorphine, a nonselective, direct-acting dopamine agonist, and amphetamine, a nonselective indirect-acting dopamine agonist, were compared for their effects on the reaction time response in rats. Animals were shaped to release a lever in response to an auditory/visual stimulus to avoid mild foot shock. The characteristics of the reaction time response of primary interest were percent successful avoidance and response latency. Apomorphine (0, 1, and 5 mg/kg, IP) significantly decreased successful avoidance, but had no effect on response latencies. Thus, the decrease in successful avoidance was not a direct result of longer latencies. Amphetamine (0, 0.5, and 1 mg/kg, IP) produced a different pattern of effects on the reaction time response. Successful avoidance was not affected by amphetamine treatment. However, response latencies were dose-dependently decreased in response to amphetamine. These results demonstrate that dopamine receptor stimulation by different dopamine agonists produces a different pattern of effects on the characteristics of the reaction time response. In addition, these results demonstrate that successful avoidance can be modulated independently of response latencies.