The role of dopamine in the formation of gastric ulcers in rats
A single dose of the dopamine agonists L-dopa, bromocriptine or apomorphine produced a protective effect by significantly shortening of the length of stomach ulcerations. A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending t...
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| Veröffentlicht in: | European journal of pharmacology 1985-01, Vol.112 (1), p.127-128 |
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| container_end_page | 128 |
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| container_issue | 1 |
| container_start_page | 127 |
| container_title | European journal of pharmacology |
| container_volume | 112 |
| creator | Sikirić, Predrag Geber, Juraj Suchanek, Ernest Ivanović, Drago Gjuriš, Veljko Aleksić, Jelena Reić, Petar Marović, Anton |
| description | A single dose of the dopamine agonists L-dopa, bromocriptine or apomorphine produced a protective effect by significantly shortening of the length of stomach ulcerations. A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending the length of stomach ulcerations. These results point to the fact that dopamine is involved in the rise and development of experimental stomach ulcers. |
| doi_str_mv | 10.1016/0014-2999(85)90249-3 |
| format | Article |
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A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending the length of stomach ulcerations. These results point to the fact that dopamine is involved in the rise and development of experimental stomach ulcers.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(85)90249-3</identifier><identifier>PMID: 4018137</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Apomorphine - pharmacology ; Applied sciences ; Biological and medical sciences ; Bromocriptine - pharmacology ; Digestive system ; Domperidone - pharmacology ; Dopamine - physiology ; Dopamine agonists ; Dopamine antagonists ; Exact sciences and technology ; Female ; Gastric ulcer ; Haloperidol - pharmacology ; Levodopa - pharmacology ; Male ; Medical sciences ; Other techniques and industries ; Pharmacology. 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A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending the length of stomach ulcerations. These results point to the fact that dopamine is involved in the rise and development of experimental stomach ulcers.</description><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Bromocriptine - pharmacology</subject><subject>Digestive system</subject><subject>Domperidone - pharmacology</subject><subject>Dopamine - physiology</subject><subject>Dopamine agonists</subject><subject>Dopamine antagonists</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Gastric ulcer</subject><subject>Haloperidol - pharmacology</subject><subject>Levodopa - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other techniques and industries</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1985-01, Vol.112 (1), p.127-128 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apomorphine - pharmacology Applied sciences Biological and medical sciences Bromocriptine - pharmacology Digestive system Domperidone - pharmacology Dopamine - physiology Dopamine agonists Dopamine antagonists Exact sciences and technology Female Gastric ulcer Haloperidol - pharmacology Levodopa - pharmacology Male Medical sciences Other techniques and industries Pharmacology. Drug treatments Rats Rats, Inbred Strains Stomach Ulcer - physiopathology Sulpiride - pharmacology |
| title | The role of dopamine in the formation of gastric ulcers in rats |
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