The role of dopamine in the formation of gastric ulcers in rats

A single dose of the dopamine agonists L-dopa, bromocriptine or apomorphine produced a protective effect by significantly shortening of the length of stomach ulcerations. A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending t...

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Veröffentlicht in:	European journal of pharmacology 1985-01, Vol.112 (1), p.127-128
Hauptverfasser:	Sikirić, Predrag, Geber, Juraj, Suchanek, Ernest, Ivanović, Drago, Gjuriš, Veljko, Aleksić, Jelena, Reić, Petar, Marović, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apomorphine - pharmacology Applied sciences Biological and medical sciences Bromocriptine - pharmacology Digestive system Domperidone - pharmacology Dopamine - physiology Dopamine agonists Dopamine antagonists Exact sciences and technology Female Gastric ulcer Haloperidol - pharmacology Levodopa - pharmacology Male Medical sciences Other techniques and industries Pharmacology. Drug treatments Rats Rats, Inbred Strains Stomach Ulcer - physiopathology Sulpiride - pharmacology
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Zusammenfassung:	A single dose of the dopamine agonists L-dopa, bromocriptine or apomorphine produced a protective effect by significantly shortening of the length of stomach ulcerations. A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending the length of stomach ulcerations. These results point to the fact that dopamine is involved in the rise and development of experimental stomach ulcers.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(85)90249-3