A novel adhesion protein expressed by ciliated epithelium, hemocytes, and leukemia cells in soft-shell clams

The ontogeny of circulating hemocytes and tumor cells in mollusks has been approached using monoclonal antibodies to normal cells. A monoclonal antibody, previously shown to identify an adhesion related protein (p130), has been used to define the reactivity of cells in tissues from normal soft-shell...

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Veröffentlicht in:	Developmental and comparative immunology 1993, Vol.17 (6), p.475-481
Hauptverfasser:	Smolowitz, Roxanna M., Reinisch, Carol L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Antibody Biochemistry. Physiology. Immunology Biological and medical sciences Bivalvia - cytology Bivalvia - immunology Cell Adhesion Molecules - analysis Cilia Connective tissue Connective Tissue Cells Epithelium Epithelium - immunology Fundamental and applied biological sciences. Psychology Hemocytes Hemocytes - immunology Immunoenzyme Techniques - veterinary Invertebrates Leukemia Leukemia - immunology Leukemia - veterinary Marine Mice Mice, Inbred BALB C Mollusca Mya arenaria Ontogeny Physiology. Development
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Zusammenfassung:	The ontogeny of circulating hemocytes and tumor cells in mollusks has been approached using monoclonal antibodies to normal cells. A monoclonal antibody, previously shown to identify an adhesion related protein (p130), has been used to define the reactivity of cells in tissues from normal soft-shell clams ( Mya arenaria) and soft-shell clams with leukemia. Using immunoperoxidase technology, we have determined that hemocytes, connective tissue cells, and a subset of leukemia cells that are adherent share a cross-reactive epitope with cilia.
ISSN:	0145-305X 1879-0089
DOI:	10.1016/S0145-305X(05)80003-5