Cross-tolerance between ethanol and chlordiazepoxide
Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, et...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 1985-03, Vol.2 (2), p.209-213 |
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| container_title | Alcohol (Fayetteville, N.Y.) |
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| creator | Chan, Arthur W.K. Schanley, Donna L. Aleo, Michael D. Leong, Florence W. |
| description | Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, ethanol-pretreated (3.5 g/kg, 24 hr earlier) mice, when injected with CDP (30 mg/kg), showed cross-tolerance to CDP. The cross-tolerance was short-lived ( |
| doi_str_mv | 10.1016/0741-8329(85)90047-3 |
| format | Article |
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C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, ethanol-pretreated (3.5 g/kg, 24 hr earlier) mice, when injected with CDP (30 mg/kg), showed cross-tolerance to CDP. The cross-tolerance was short-lived (<48 hr). On the other hand, CDP-pretreated mice (30 mg/kg, 24 hr earlier) did not show cross-tolerance to ethanol. The lack of a reciprocating effect of CDP-pretreatment was not likely to be due to the difference in initial dosage between ethanol and CDP. It may be due to different rates of tolerance development or different mechanisms of actions between CDP and ethanol. Mice chronically treated with ethanol also showed a similar degree of cross-tolerance to CDP compared to those exposed to an acute dose of ethanol.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/0741-8329(85)90047-3</identifier><identifier>PMID: 4015844</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Chlordiazepoxide ; Chlordiazepoxide - pharmacology ; Cross-tolerance ; Drug Tolerance ; Ethanol ; Ethanol - pharmacology ; Hypothermia ; Hypothermia, Induced ; Male ; Mice ; Mice, Inbred C57BL ; Tolerance</subject><ispartof>Alcohol (Fayetteville, N.Y.), 1985-03, Vol.2 (2), p.209-213</ispartof><rights>1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-5bf40968c70b22e398cef70e442019b7df3119bff0541d1608108e532a8703663</citedby><cites>FETCH-LOGICAL-c357t-5bf40968c70b22e398cef70e442019b7df3119bff0541d1608108e532a8703663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0741-8329(85)90047-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4015844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Arthur W.K.</creatorcontrib><creatorcontrib>Schanley, Donna L.</creatorcontrib><creatorcontrib>Aleo, Michael D.</creatorcontrib><creatorcontrib>Leong, Florence W.</creatorcontrib><title>Cross-tolerance between ethanol and chlordiazepoxide</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, ethanol-pretreated (3.5 g/kg, 24 hr earlier) mice, when injected with CDP (30 mg/kg), showed cross-tolerance to CDP. The cross-tolerance was short-lived (<48 hr). On the other hand, CDP-pretreated mice (30 mg/kg, 24 hr earlier) did not show cross-tolerance to ethanol. The lack of a reciprocating effect of CDP-pretreatment was not likely to be due to the difference in initial dosage between ethanol and CDP. It may be due to different rates of tolerance development or different mechanisms of actions between CDP and ethanol. Mice chronically treated with ethanol also showed a similar degree of cross-tolerance to CDP compared to those exposed to an acute dose of ethanol.</description><subject>Animals</subject><subject>Chlordiazepoxide</subject><subject>Chlordiazepoxide - pharmacology</subject><subject>Cross-tolerance</subject><subject>Drug Tolerance</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Tolerance</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EKqXwBiBlQjAEjmMndhYkFHGTKrHAbDn2iWqUxsVOuT09Ca06Mp3hvxz9HyGnFK4o0OIaBKepZFl5IfPLEoCLlO2RKZWCpYXM2D6Z7iyH5CjGNwAQQpQTMuFAc8n5lPAq-BjT3rcYdGcwqbH_ROwS7Be6822iO5uYReuDdfoHV_7LWTwmB41uI55s74y83t-9VI_p_Pnhqbqdp4blok_zuuFQFtIIqLMMWSkNNgKQ8wxoWQvbMDrcpoGcU0sLkBQk5izTUgArCjYj55veVfDva4y9WrposG11h34dlSiyYSFjg5FvjGZcE7BRq-CWOnwrCmqEpUYSaiShZK7-YKkxdrbtX9dLtLvQls6g32x0HEZ-OAwqGocDJesCml5Z7_5_8AueQXcc</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Chan, Arthur W.K.</creator><creator>Schanley, Donna L.</creator><creator>Aleo, Michael D.</creator><creator>Leong, Florence W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Cross-tolerance between ethanol and chlordiazepoxide</title><author>Chan, Arthur W.K. ; Schanley, Donna L. ; Aleo, Michael D. ; Leong, Florence W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-5bf40968c70b22e398cef70e442019b7df3119bff0541d1608108e532a8703663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Chlordiazepoxide</topic><topic>Chlordiazepoxide - pharmacology</topic><topic>Cross-tolerance</topic><topic>Drug Tolerance</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Arthur W.K.</creatorcontrib><creatorcontrib>Schanley, Donna L.</creatorcontrib><creatorcontrib>Aleo, Michael D.</creatorcontrib><creatorcontrib>Leong, Florence W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Arthur W.K.</au><au>Schanley, Donna L.</au><au>Aleo, Michael D.</au><au>Leong, Florence W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-tolerance between ethanol and chlordiazepoxide</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>1985-03</date><risdate>1985</risdate><volume>2</volume><issue>2</issue><spage>209</spage><epage>213</epage><pages>209-213</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><abstract>Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, ethanol-pretreated (3.5 g/kg, 24 hr earlier) mice, when injected with CDP (30 mg/kg), showed cross-tolerance to CDP. The cross-tolerance was short-lived (<48 hr). On the other hand, CDP-pretreated mice (30 mg/kg, 24 hr earlier) did not show cross-tolerance to ethanol. The lack of a reciprocating effect of CDP-pretreatment was not likely to be due to the difference in initial dosage between ethanol and CDP. It may be due to different rates of tolerance development or different mechanisms of actions between CDP and ethanol. Mice chronically treated with ethanol also showed a similar degree of cross-tolerance to CDP compared to those exposed to an acute dose of ethanol.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4015844</pmid><doi>10.1016/0741-8329(85)90047-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Alcohol (Fayetteville, N.Y.), 1985-03, Vol.2 (2), p.209-213 |
| issn | 0741-8329 1873-6823 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Chlordiazepoxide Chlordiazepoxide - pharmacology Cross-tolerance Drug Tolerance Ethanol Ethanol - pharmacology Hypothermia Hypothermia, Induced Male Mice Mice, Inbred C57BL Tolerance |
| title | Cross-tolerance between ethanol and chlordiazepoxide |
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