Cross-tolerance between ethanol and chlordiazepoxide

Cross-tolerance between ethanol and chlordiazepoxide

Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, et...

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Veröffentlicht in:Alcohol (Fayetteville, N.Y.) N.Y.), 1985-03, Vol.2 (2), p.209-213
Hauptverfasser: Chan, Arthur W.K., Schanley, Donna L., Aleo, Michael D., Leong, Florence W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chlordiazepoxide
Chlordiazepoxide - pharmacology
Cross-tolerance
Drug Tolerance
Ethanol
Ethanol - pharmacology
Hypothermia
Hypothermia, Induced
Male
Mice
Mice, Inbred C57BL
Tolerance
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Zusammenfassung:Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, ethanol-pretreated (3.5 g/kg, 24 hr earlier) mice, when injected with CDP (30 mg/kg), showed cross-tolerance to CDP. The cross-tolerance was short-lived (
ISSN:0741-8329
1873-6823
DOI:10.1016/0741-8329(85)90047-3