The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart

In isolated guinea-pig heart submitted to hypoxia in the absence of substrate and subsequent reoxygenation 1–20 mM taurine decreases LDH released and ventricular arrythymias, and the recovery of normal electrical and mechanical activity is increased. The taurine effect is dose-dependent, and is not...

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Veröffentlicht in:	Biochemical pharmacology 1985-08, Vol.34 (15), p.2611-2615
Hauptverfasser:	Franconi, Flavia, Stendardi, Isabella, Failli, Paola, Matucci, Rosanna, Baccaro, Cecilia, Montorsi, Lucia, Bandinelli, Renzo, Giotti, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - etiology Biological and medical sciences Calcium - analysis Cardiovascular system Dose-Response Relationship, Drug Glucose - pharmacology Guinea Pigs Heart - drug effects In Vitro Techniques L-Lactate Dehydrogenase - metabolism Medical sciences Miscellaneous Myocardium - metabolism Oxygen - pharmacology Pharmacology. Drug treatments Taurine - pharmacology
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Zusammenfassung:	In isolated guinea-pig heart submitted to hypoxia in the absence of substrate and subsequent reoxygenation 1–20 mM taurine decreases LDH released and ventricular arrythymias, and the recovery of normal electrical and mechanical activity is increased. The taurine effect is dose-dependent, and is not mimicked by β-alanine. Moreover, taurine reduces the increase in calcium gain of reoxygenated heart.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(85)90556-8