p-Chlorophenylalanine damages pancreatic acinar cell of the chicken

p-Chlorophenylalanine damages pancreatic acinar cell of the chicken

1. Birds were injected intraperitoneally with dl -p- chlorophenylalanine ( p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-Cf treatment. 2. The application of acetylcholine (5.50 × 10 −9 to 5....

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Veröffentlicht in:Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Comparative pharmacology and toxicology, 1993-11, Vol.106 (3), p.667-670
Hauptverfasser: Furuse, Mitsuhiro, Satoh, Say, Yang, Sung-Ik, Watanabe, Tohru, Okumura, Jun-Ichi
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - pharmacology
Amylases - metabolism
Animals
Biological and medical sciences
Chickens
Exocrine pancreas
Fenclonine - pharmacology
Fundamental and applied biological sciences. Psychology
Male
Organ Size - drug effects
Pancreas - cytology
Pancreas - drug effects
Pancreas - enzymology
Vertebrates: digestive system
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Zusammenfassung:1. Birds were injected intraperitoneally with dl -p- chlorophenylalanine ( p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-Cf treatment. 2. The application of acetylcholine (5.50 × 10 −9 to 5.50 × 10 −5 M) caused a dose dependent increase in amylase release from the superfused segment of pancreas, although the response significantly decreased in the pancreatic segment treated with p-CP, compared with the control.
ISSN:0742-8413
DOI:10.1016/0742-8413(93)90225-A