L1CAM ubiquitination facilitates its lysosomal degradation

The cell adhesion molecule L1 is implicated in several processes in the developing and adult nervous system. Intracellular trafficking of L1 is important for cell migration, neurite growth and adhesion. We demonstrate here that L1 is ubiquitinated at the plasma membrane and in early endosomes. Mono-...

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Veröffentlicht in:FEBS letters 2010-11, Vol.584 (21), p.4475-4480
Hauptverfasser: Schäfer, Michael K.E., Schmitz, Brigitte, Diestel, Simone
Format: Artikel
Sprache:eng
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Zusammenfassung:The cell adhesion molecule L1 is implicated in several processes in the developing and adult nervous system. Intracellular trafficking of L1 is important for cell migration, neurite growth and adhesion. We demonstrate here that L1 is ubiquitinated at the plasma membrane and in early endosomes. Mono-ubiquitination regulates L1 intracellular trafficking by enhancing its lysosomal degradation. We propose that L1’s ubiquitination might be an additional mechanism to control its re-appearance at the cell surface thereby influencing processes like neurite growth and cell adhesion.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2010.10.011