Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14

An improved method for detecting four Np-1 (purine nucleoside phosphorylase) alleles in mouse erythrocytes by cellulose acetate electrophoresis is described. The previous linkage of Np-1 and Es-10 (esterase-10) was confirmed, with a map distance of 13.0 +/- 2.6 cM. Np-2 was detected by either specif...

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Veröffentlicht in:	Biochemical genetics 1985-04, Vol.23 (3-4), p.347-356
Hauptverfasser:	LUKEY, T, NEOTE, K, LOMAN, J. F, UNGER, A. E, BIDDLE, F. G, SNYDER, F. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carboxylesterase Carboxylic Ester Hydrolases - genetics Chromosome Mapping Classical genetics, quantitative genetics, hybrids Electrophoresis, Cellulose Acetate Electrophoresis, Starch Gel Fundamental and applied biological sciences. Psychology Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Mice - genetics Mice, Inbred Strains Pentosyltransferases - genetics Purine-Nucleoside Phosphorylase - genetics Vertebrata
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Zusammenfassung:	An improved method for detecting four Np-1 (purine nucleoside phosphorylase) alleles in mouse erythrocytes by cellulose acetate electrophoresis is described. The previous linkage of Np-1 and Es-10 (esterase-10) was confirmed, with a map distance of 13.0 +/- 2.6 cM. Np-2 was detected by either specific activity assay or starch gel electrophoresis and shown to be linked to Es-10, 15.9 +/- 3.1 cM, on chromosome 14. No recombinants between Np-1 and Np-2 were observed in 52 offspring, indicating either that these loci are either closely associated or that Np-2 represents simply a property of existing allelic products of the Np-1 locus.
ISSN:	0006-2928 1573-4927
DOI:	10.1007/BF00504331