Protective Effect of Hypoxia against Irradiation Injury of the Rat Bone Marrow and Spleen.

Protective Effect of Hypoxia against Irradiation Injury of the Rat Bone Marrow and Spleen.

Summary 1. Rats irradiated in a hypoxic atmosphere show a slightly higher cellularity and much greater rate of DNA synthesis in the bone marrow and spleen after 96 hours than rats irradiated at ground level. 2. Thirty hours of intermittent hypoxia preceding irradiation at low oxygen tensions does no...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1954-05, Vol.86 (1), p.159-161
Hauptverfasser: Rambach, W. A., Alt, H. L., Cooper, John A. D.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BONE MARROW
CYTOLOGY
DNA
EFFICIENCY
ENVIRONMENT
Hypoxia
MITOSIS
NUCLEIC ACIDS
Old Medline
OXYGEN
QUANTITY RATIO
Radiation
Radiation Injuries
RADIATION PROTECTION
RADIOBIOLOGY
RATS
SPLEEN
Spleen - radiation effects
X-Rays
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Zusammenfassung:Summary 1. Rats irradiated in a hypoxic atmosphere show a slightly higher cellularity and much greater rate of DNA synthesis in the bone marrow and spleen after 96 hours than rats irradiated at ground level. 2. Thirty hours of intermittent hypoxia preceding irradiation at low oxygen tensions does not give additional protection. 3. A striking parallelism exists in the cellular reactions in the bone marrow and spleen following irradiation, both at normal atmospheric pressures and at low oxygen pressure. 4. Irradiation of animals at low oxygen pressures appears to reduce the biological effectiveness of 800 r on the bone marrow to 600 r.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-86-21038