Effect of captopril on NaK ATPase and Mg ATPase activities of erythrocyte ghost membranes

Captopril has a known hypotensive action derived from the inhibition of the converting enzyme (Kininase II). To investigate whether other mechanism may contribute to vasodilation, NaK ATPase and Mg ATPase activities on ghost red blood cells membranes were examined in the presence of the drug. The r...

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Veröffentlicht in:	Pharmacological research communications 1985-04, Vol.17 (4), p.323-330
Hauptverfasser:	Santoro, Federico M., de la Riva, Ignacio J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism adenosinetriphosphatase Antihypertensive agents Biological and medical sciences Ca(2+) Mg(2+)-ATPase captopril Captopril - pharmacology Cardiovascular system Erythrocyte Membrane - enzymology erythrocytes Humans In Vitro Techniques man Medical sciences Ouabain - pharmacology Pharmacology. Drug treatments Proline - analogs & derivatives Sodium-Potassium-Exchanging ATPase - metabolism
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Beschreibung
Zusammenfassung:	Captopril has a known hypotensive action derived from the inhibition of the converting enzyme (Kininase II). To investigate whether other mechanism may contribute to vasodilation, NaK ATPase and Mg ATPase activities on ghost red blood cells membranes were examined in the presence of the drug. The results show a stimulation of Mg ATPase activity and an inhibition of NaK ATPase activity in a concentration dependent manner. The latter action does not seem to be related to a vasodilator effect.
ISSN:	0031-6989 1879-2936
DOI:	10.1016/0031-6989(85)90012-8