Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherich...

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Veröffentlicht in:	Nature (London) 1985-06, Vol.315 (6021), p.641-647
Hauptverfasser:	March, Carl J, Mosley, Bruce, Larsen, Alf, Cerretti, Douglas Pat, Braedt, Gary, Price, Virginia, Gillis, Steven, Henney, Christopher S, Kronheim, Shirley R, Grabstein, Kenneth, Conlon, Paul J, Hopp, Thomas P, Cosman, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Restriction Enzymes DNA, Circular - genetics Gene Expression Regulation Humanities and Social Sciences Humans Interleukin-1 - analysis Interleukin-1 - genetics multidisciplinary Plasmids RNA, Messenger - isolation & purification Science Science (multidisciplinary) Xenopus
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Zusammenfassung:	Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/315641a0