Hemodynamic Effects of Digoxin on Congestive Heart Failure in Old Myocardial Infarction, Dilated Cardiomyopathy, Acute Myocardial Infarction and Mitral Stenosis
The hemodynamic effects of digoxin (0.01mg/Kg) on congestive heart failure were compared in 32 patients with old myocardial infarction (OMI) (n=9), dilated cardiomyopathy (DCM) (n=10), acute myocardial infarction (AMI) (n=5) and mitral stenosis (MS) (n=8). The responses of heart rate (HR) and pulmon...
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| Veröffentlicht in: | Japanese Heart Journal 1985, Vol.26(2), pp.155-164 |
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| creator | KUROGANE, Keiji FUJITANI, Kazuhiro FUKUZAKI, Hisashi |
| description | The hemodynamic effects of digoxin (0.01mg/Kg) on congestive heart failure were compared in 32 patients with old myocardial infarction (OMI) (n=9), dilated cardiomyopathy (DCM) (n=10), acute myocardial infarction (AMI) (n=5) and mitral stenosis (MS) (n=8). The responses of heart rate (HR) and pulmonary capillary pressure (PCP) to digoxin in OMI, DCM and MS were marked but different in each of these groups and no significant changes were found in patients with AMI. The responses of cardiac index (CI) to digoxin in patients with OMI and DCM in whom left ventricular myocardial contractile force was impaired were divided into 2 groups (Group 1: CI increased more than 15% and Group 2: less than 15%). In Group 1, both CI and percent fractional shortening (%FS) before digoxin administration were lower than in Group 2, i.e., 1.97±0.27 vs 2.80±0.48L/min/m2 (p |
| doi_str_mv | 10.1536/ihj.26.155 |
| format | Article |
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The responses of heart rate (HR) and pulmonary capillary pressure (PCP) to digoxin in OMI, DCM and MS were marked but different in each of these groups and no significant changes were found in patients with AMI. The responses of cardiac index (CI) to digoxin in patients with OMI and DCM in whom left ventricular myocardial contractile force was impaired were divided into 2 groups (Group 1: CI increased more than 15% and Group 2: less than 15%). In Group 1, both CI and percent fractional shortening (%FS) before digoxin administration were lower than in Group 2, i.e., 1.97±0.27 vs 2.80±0.48L/min/m2 (p<0.001) and 10.9±8.0 vs 19.5±11.9% (p<0.05), respectively. In MS, CI increased after digoxin administration only in the 2 patients with low CI and rapid HR in the control state. These results indicate that the mode of hemodynamic response to digoxin is considerably different in various diseases. They further suggest that digoxin should not be used in the early phase of AMT, although digoxin was of great clinical benefit in patients with OMI and DCM through such mechanisms as its positive inotropic and negative chronotropic effects and lowering of PCP.</description><identifier>ISSN: 0021-4868</identifier><identifier>EISSN: 1348-673X</identifier><identifier>DOI: 10.1536/ihj.26.155</identifier><identifier>PMID: 4009960</identifier><identifier>CODEN: JHEJAR</identifier><language>eng</language><publisher>Tokyo: International Heart Journal Association</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiomyopathy, Dilated - complications ; Cardiomyopathy, Dilated - physiopathology ; Cardiotonic agents ; Cardiovascular system ; Congestive heart failure ; Digoxin ; Digoxin - pharmacology ; Female ; Heart Failure - etiology ; Heart Failure - physiopathology ; Heart Rate - drug effects ; Hemodynamics ; Hemodynamics - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Mitral Valve Stenosis - complications ; Mitral Valve Stenosis - physiopathology ; Myocardial Contraction - drug effects ; Myocardial Infarction - complications ; Myocardial Infarction - physiopathology ; Pharmacology. Drug treatments ; Pulmonary Wedge Pressure - drug effects</subject><ispartof>Japanese Heart Journal, 1985, Vol.26(2), pp.155-164</ispartof><rights>by International Heart Journal Association</rights><rights>1985 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9174588$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4009960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUROGANE, Keiji</creatorcontrib><creatorcontrib>FUJITANI, Kazuhiro</creatorcontrib><creatorcontrib>FUKUZAKI, Hisashi</creatorcontrib><title>Hemodynamic Effects of Digoxin on Congestive Heart Failure in Old Myocardial Infarction, Dilated Cardiomyopathy, Acute Myocardial Infarction and Mitral Stenosis</title><title>Japanese Heart Journal</title><addtitle>Jpn Heart J</addtitle><description>The hemodynamic effects of digoxin (0.01mg/Kg) on congestive heart failure were compared in 32 patients with old myocardial infarction (OMI) (n=9), dilated cardiomyopathy (DCM) (n=10), acute myocardial infarction (AMI) (n=5) and mitral stenosis (MS) (n=8). The responses of heart rate (HR) and pulmonary capillary pressure (PCP) to digoxin in OMI, DCM and MS were marked but different in each of these groups and no significant changes were found in patients with AMI. The responses of cardiac index (CI) to digoxin in patients with OMI and DCM in whom left ventricular myocardial contractile force was impaired were divided into 2 groups (Group 1: CI increased more than 15% and Group 2: less than 15%). In Group 1, both CI and percent fractional shortening (%FS) before digoxin administration were lower than in Group 2, i.e., 1.97±0.27 vs 2.80±0.48L/min/m2 (p<0.001) and 10.9±8.0 vs 19.5±11.9% (p<0.05), respectively. In MS, CI increased after digoxin administration only in the 2 patients with low CI and rapid HR in the control state. These results indicate that the mode of hemodynamic response to digoxin is considerably different in various diseases. They further suggest that digoxin should not be used in the early phase of AMT, although digoxin was of great clinical benefit in patients with OMI and DCM through such mechanisms as its positive inotropic and negative chronotropic effects and lowering of PCP.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiomyopathy, Dilated - complications</subject><subject>Cardiomyopathy, Dilated - physiopathology</subject><subject>Cardiotonic agents</subject><subject>Cardiovascular system</subject><subject>Congestive heart failure</subject><subject>Digoxin</subject><subject>Digoxin - pharmacology</subject><subject>Female</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitral Valve Stenosis - complications</subject><subject>Mitral Valve Stenosis - physiopathology</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Wedge Pressure - drug effects</subject><issn>0021-4868</issn><issn>1348-673X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUGP0zAQhS0EWkrhwh3JB8QBbRY7TtzkuAq7dKVFewAkbpFjj1tXjl1sB5F_w0_FUaueuNgjf8_vaWYQekvJDa0Z_2T2h5uS57p-hlaUVU3BN-znc7QipKRF1fDmJXoV44EQysuGXaGripC25WSF_m5h9Gp2YjQS32kNMkXsNf5sdv6Pcdg73Hm3g5jMb8BbECHhe2HsFABn_GQV_jp7KYIywuIHp0WQyXh3nR2sSKBwtzA_zv4o0n6-xrdySvD_T1i4bGdSyK_fEjgfTXyNXmhhI7w532v04_7ue7ctHp--PHS3j4WsGUtF3fKWlBWRULcAmlQD3VRcMgqKQs0JEVxVTQmVoqodNKX1IEpGKz0ordWGsTX6cPI9Bv9ryv32o4kSrBUO_BT7DacNbfO41-jjSSiDjzGA7o_BjCLMPSX9so4-r6Mvea4X8buz6zSMoC7S8_wzf3_mIkphdRBOmniRtbmJummyrDvJDjGJHVx43oaRFpZEmu2W1PJ05PALlXsRenDsH1c8rOM</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>KUROGANE, Keiji</creator><creator>FUJITANI, Kazuhiro</creator><creator>FUKUZAKI, Hisashi</creator><general>International Heart Journal Association</general><general>Japanese Heart Journal Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Hemodynamic Effects of Digoxin on Congestive Heart Failure in Old Myocardial Infarction, Dilated Cardiomyopathy, Acute Myocardial Infarction and Mitral Stenosis</title><author>KUROGANE, Keiji ; FUJITANI, Kazuhiro ; FUKUZAKI, Hisashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-59690240ce59eef04b1746c31ed1e5600a6d482e4d1d9bf115ba2314fbdffd733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiomyopathy, Dilated - complications</topic><topic>Cardiomyopathy, Dilated - physiopathology</topic><topic>Cardiotonic agents</topic><topic>Cardiovascular system</topic><topic>Congestive heart failure</topic><topic>Digoxin</topic><topic>Digoxin - pharmacology</topic><topic>Female</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitral Valve Stenosis - complications</topic><topic>Mitral Valve Stenosis - physiopathology</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Wedge Pressure - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>KUROGANE, Keiji</creatorcontrib><creatorcontrib>FUJITANI, Kazuhiro</creatorcontrib><creatorcontrib>FUKUZAKI, Hisashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUROGANE, Keiji</au><au>FUJITANI, Kazuhiro</au><au>FUKUZAKI, Hisashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemodynamic Effects of Digoxin on Congestive Heart Failure in Old Myocardial Infarction, Dilated Cardiomyopathy, Acute Myocardial Infarction and Mitral Stenosis</atitle><jtitle>Japanese Heart Journal</jtitle><addtitle>Jpn Heart J</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>26</volume><issue>2</issue><spage>155</spage><epage>164</epage><pages>155-164</pages><issn>0021-4868</issn><eissn>1348-673X</eissn><coden>JHEJAR</coden><abstract>The hemodynamic effects of digoxin (0.01mg/Kg) on congestive heart failure were compared in 32 patients with old myocardial infarction (OMI) (n=9), dilated cardiomyopathy (DCM) (n=10), acute myocardial infarction (AMI) (n=5) and mitral stenosis (MS) (n=8). The responses of heart rate (HR) and pulmonary capillary pressure (PCP) to digoxin in OMI, DCM and MS were marked but different in each of these groups and no significant changes were found in patients with AMI. The responses of cardiac index (CI) to digoxin in patients with OMI and DCM in whom left ventricular myocardial contractile force was impaired were divided into 2 groups (Group 1: CI increased more than 15% and Group 2: less than 15%). In Group 1, both CI and percent fractional shortening (%FS) before digoxin administration were lower than in Group 2, i.e., 1.97±0.27 vs 2.80±0.48L/min/m2 (p<0.001) and 10.9±8.0 vs 19.5±11.9% (p<0.05), respectively. In MS, CI increased after digoxin administration only in the 2 patients with low CI and rapid HR in the control state. These results indicate that the mode of hemodynamic response to digoxin is considerably different in various diseases. They further suggest that digoxin should not be used in the early phase of AMT, although digoxin was of great clinical benefit in patients with OMI and DCM through such mechanisms as its positive inotropic and negative chronotropic effects and lowering of PCP.</abstract><cop>Tokyo</cop><pub>International Heart Journal Association</pub><pmid>4009960</pmid><doi>10.1536/ihj.26.155</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - physiopathology Cardiotonic agents Cardiovascular system Congestive heart failure Digoxin Digoxin - pharmacology Female Heart Failure - etiology Heart Failure - physiopathology Heart Rate - drug effects Hemodynamics Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Mitral Valve Stenosis - complications Mitral Valve Stenosis - physiopathology Myocardial Contraction - drug effects Myocardial Infarction - complications Myocardial Infarction - physiopathology Pharmacology. Drug treatments Pulmonary Wedge Pressure - drug effects |
| title | Hemodynamic Effects of Digoxin on Congestive Heart Failure in Old Myocardial Infarction, Dilated Cardiomyopathy, Acute Myocardial Infarction and Mitral Stenosis |
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