Hemodynamic Effects of Digoxin on Congestive Heart Failure in Old Myocardial Infarction, Dilated Cardiomyopathy, Acute Myocardial Infarction and Mitral Stenosis

The hemodynamic effects of digoxin (0.01mg/Kg) on congestive heart failure were compared in 32 patients with old myocardial infarction (OMI) (n=9), dilated cardiomyopathy (DCM) (n=10), acute myocardial infarction (AMI) (n=5) and mitral stenosis (MS) (n=8). The responses of heart rate (HR) and pulmonary capillary pressure (PCP) to digoxin in OMI, DCM and MS were marked but different in each of these groups and no significant changes were found in patients with AMI. The responses of cardiac index (CI) to digoxin in patients with OMI and DCM in whom left ventricular myocardial contractile force was impaired were divided into 2 groups (Group 1: CI increased more than 15% and Group 2: less than 15%). In Group 1, both CI and percent fractional shortening (%FS) before digoxin administration were lower than in Group 2, i.e., 1.97±0.27 vs 2.80±0.48L/min/m2 (p