Benzodiazepine receptor binding in vivo with [3H]-Ro 15-1788

In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific to nonspecific ratios are ob...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Life Sci.; (United States) 1985-07, Vol.37 (4), p.345-355
Hauptverfasser:	GOEDERS, N. E, KUHAR, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Animals Autoradiography BASIC BIOLOGICAL SCIENCES Benzodiazepinones - metabolism Biological and medical sciences Brain - metabolism CENTRAL NERVOUS SYSTEM AGENTS CHEMICAL BONDS Clonazepam - metabolism DRUGS Flumazenil Flunitrazepam - metabolism In Vitro Techniques IN VIVO ISOTOPE APPLICATIONS LABELLED COMPOUNDS Male Medical sciences Mice Mice, Inbred ICR Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology PSYCHOTROPIC DRUGS RECEPTORS Receptors, GABA-A - metabolism Time Factors TRACER TECHNIQUES TRANQUILIZERS Tritium TRITIUM COMPOUNDS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homogenization or washing. [3H]-Flunitrazepam and [3H]-clonazepam did not exhibit useful in vivo receptor binding.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(85)90505-3