NEW ANTIVIRAL ANTIBIOTICS, KISTAMICINS A AND B: I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.
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| Veröffentlicht in: | Journal of antibiotics 1993/12/25, Vol.46(12), pp.1804-1811 |
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| container_end_page | 1811 |
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| container_issue | 12 |
| container_start_page | 1804 |
| container_title | Journal of antibiotics |
| container_volume | 46 |
| creator | NARUSE, NOBUAKI TENMYO, OSAMU KOBARU, SEIKICHI HATORI, MASAMI TOMITA, KOJI HAMAGISHI, YASUTARO OKI, TOSHIKAZU |
| description | A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria. |
| doi_str_mv | 10.7164/antibiotics.46.1804 |
| format | Article |
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TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>NARUSE, NOBUAKI ; TENMYO, OSAMU ; KOBARU, SEIKICHI ; HATORI, MASAMI ; TOMITA, KOJI ; HAMAGISHI, YASUTARO ; OKI, TOSHIKAZU</creator><creatorcontrib>NARUSE, NOBUAKI ; TENMYO, OSAMU ; KOBARU, SEIKICHI ; HATORI, MASAMI ; TOMITA, KOJI ; HAMAGISHI, YASUTARO ; OKI, TOSHIKAZU</creatorcontrib><description>A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.46.1804</identifier><identifier>PMID: 8294237</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Actinomycetales - chemistry ; Actinomycetales - classification ; Actinomycetales - metabolism ; Animals ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antiviral Agents - isolation & purification ; Antiviral Agents - metabolism ; Antiviral Agents - pharmacology ; Bacterial Proteins - chemistry ; Bacterial Proteins - isolation & purification ; Bacterial Proteins - pharmacology ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Dogs ; Fermentation ; General pharmacology ; HeLa Cells ; Herpes Simplex - drug therapy ; Humans ; Influenza A virus - drug effects ; Influenza, Human - drug therapy ; Magnetic Resonance Spectroscopy ; Medical sciences ; Peptides ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Simplexvirus - drug effects ; Vero Cells</subject><ispartof>The Journal of Antibiotics, 1993/12/25, Vol.46(12), pp.1804-1811</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-fcfa6943c890e648df4a01bbddd7420a0f0d56f506422cef8a15dadc7e7af5d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3897669$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8294237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NARUSE, NOBUAKI</creatorcontrib><creatorcontrib>TENMYO, OSAMU</creatorcontrib><creatorcontrib>KOBARU, SEIKICHI</creatorcontrib><creatorcontrib>HATORI, MASAMI</creatorcontrib><creatorcontrib>TOMITA, KOJI</creatorcontrib><creatorcontrib>HAMAGISHI, YASUTARO</creatorcontrib><creatorcontrib>OKI, TOSHIKAZU</creatorcontrib><title>NEW ANTIVIRAL ANTIBIOTICS, KISTAMICINS A AND B: I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.</description><subject>Actinomycetales - chemistry</subject><subject>Actinomycetales - classification</subject><subject>Actinomycetales - metabolism</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - metabolism</subject><subject>Antiviral Agents - pharmacology</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - isolation & purification</subject><subject>Bacterial Proteins - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Dogs</subject><subject>Fermentation</subject><subject>General pharmacology</subject><subject>HeLa Cells</subject><subject>Herpes Simplex - drug therapy</subject><subject>Humans</subject><subject>Influenza A virus - drug effects</subject><subject>Influenza, Human - drug therapy</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Peptides</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Simplexvirus - drug effects</subject><subject>Vero Cells</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwBQipC8SKBNtxbGeZlgIRJZVogKXl-gGp0gdxuuDvSdooYsdmZqR7Zu7oAnCJoM8QJXdyXeWLfFPlyvmE-ohDcgT6iHPkIUKjY9CHECOPcwxPwZlzSwgDFjDeAz2OI4ID1gd-OvkYxmmWvCev8XQ_jZJZloznt8PnZJ7FL8k4SefDuJbuh6NzcGJl4cxF2wfg7WGSjZ-86ewxGcdTT5GQEc8qK2lEAsUjaCjh2hIJ0WKhtWYEQwkt1CG1IaQEY2UslyjUUitmmLShxsEA3BzubsvN9864Sqxyp0xRyLXZ7JxgFDGGKfwXRPUbLOINGBxAVW6cK40V2zJfyfJHICiaOMWfOAWhoomz3rpqz-8WK6O7nTa_Wr9udemULGwp1yp3HRbwiFEa1Vh6wJaukp-m02VZuxXmrzWKKN_b47Y2f3Sg-pKlMOvgF6hzl0c</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>NARUSE, NOBUAKI</creator><creator>TENMYO, OSAMU</creator><creator>KOBARU, SEIKICHI</creator><creator>HATORI, MASAMI</creator><creator>TOMITA, KOJI</creator><creator>HAMAGISHI, YASUTARO</creator><creator>OKI, TOSHIKAZU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>NEW ANTIVIRAL ANTIBIOTICS, KISTAMICINS A AND B</title><author>NARUSE, NOBUAKI ; TENMYO, OSAMU ; KOBARU, SEIKICHI ; HATORI, MASAMI ; TOMITA, KOJI ; HAMAGISHI, YASUTARO ; OKI, TOSHIKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-fcfa6943c890e648df4a01bbddd7420a0f0d56f506422cef8a15dadc7e7af5d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Actinomycetales - chemistry</topic><topic>Actinomycetales - classification</topic><topic>Actinomycetales - metabolism</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - metabolism</topic><topic>Antiviral Agents - pharmacology</topic><topic>Bacterial Proteins - chemistry</topic><topic>Bacterial Proteins - isolation & purification</topic><topic>Bacterial Proteins - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Dogs</topic><topic>Fermentation</topic><topic>General pharmacology</topic><topic>HeLa Cells</topic><topic>Herpes Simplex - drug therapy</topic><topic>Humans</topic><topic>Influenza A virus - drug effects</topic><topic>Influenza, Human - drug therapy</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Peptides</topic><topic>Pharmacokinetics. 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TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1993</date><risdate>1993</risdate><volume>46</volume><issue>12</issue><spage>1804</spage><epage>1811</epage><pages>1804-1811</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>8294237</pmid><doi>10.7164/antibiotics.46.1804</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1993/12/25, Vol.46(12), pp.1804-1811 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76177260 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Actinomycetales - chemistry Actinomycetales - classification Actinomycetales - metabolism Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antiviral Agents - isolation & purification Antiviral Agents - metabolism Antiviral Agents - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - isolation & purification Bacterial Proteins - pharmacology Biological and medical sciences Chemical Phenomena Chemistry, Physical Dogs Fermentation General pharmacology HeLa Cells Herpes Simplex - drug therapy Humans Influenza A virus - drug effects Influenza, Human - drug therapy Magnetic Resonance Spectroscopy Medical sciences Peptides Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Simplexvirus - drug effects Vero Cells |
| title | NEW ANTIVIRAL ANTIBIOTICS, KISTAMICINS A AND B: I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES |
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