NEW ANTIVIRAL ANTIBIOTICS, KISTAMICINS A AND B: I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

NEW ANTIVIRAL ANTIBIOTICS, KISTAMICINS A AND B: I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.

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Veröffentlicht in:Journal of antibiotics 1993/12/25, Vol.46(12), pp.1804-1811
Hauptverfasser: NARUSE, NOBUAKI, TENMYO, OSAMU, KOBARU, SEIKICHI, HATORI, MASAMI, TOMITA, KOJI, HAMAGISHI, YASUTARO, OKI, TOSHIKAZU
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetales - chemistry
Actinomycetales - classification
Actinomycetales - metabolism
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antiviral Agents - isolation & purification
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Bacterial Proteins - chemistry
Bacterial Proteins - isolation & purification
Bacterial Proteins - pharmacology
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Dogs
Fermentation
General pharmacology
HeLa Cells
Herpes Simplex - drug therapy
Humans
Influenza A virus - drug effects
Influenza, Human - drug therapy
Magnetic Resonance Spectroscopy
Medical sciences
Peptides
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Simplexvirus - drug effects
Vero Cells
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Beschreibung
Zusammenfassung:A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1804