The Effects of Angiotensin-Converting Enzyme Inhibitors on the Clinical and Biochemical Parameters in Diabetic Nephropathy

Captopril's short-term effects on clinical and biochemical parameters were studied in 21 diabetic nephropathic patients. Their mean age was 57.50± 2.28 years; 16 of them were women and 5 were men. Eleven patients had been regulated with insulin and 10 of them had been regulated with oral antidiabetics. Fifteen patients were microalbuminuric (200 mg/daily and below albuminuria) and their mean diabetes mellitus history was 14.86± 1.44 years. Six patients had advanced diabetic nephropathy (400 mg/ daily and above albuminuria). Their mean diabetes mellitus history was 4.50± 2.87 years. Captopril in a low dose (37.5 mgldaily p.o., three separated doses) was given during 20 days. In the microalbuminuria group there were insignificant alterations in renal function, blood glucose levels, and systolic blood pressure. Diastolic blood pressure decreased significantly in this group (p