Ethanol and leucine oxidation—I. Leucine oxidation by the rat in vivo

Ethanol and leucine oxidation—I. Leucine oxidation by the rat in vivo

1. 1. The effect of ethanol upon the oxidation of leucine by the rat in vivo was determined. 2. 2. The rate of leucine oxidation was not significantly altered by chronic administration of ethanol (20% v v solution as drinking water for 28 days). 3. 3. Ethanol administered acutely (8 g kg 0.73) signi...

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Veröffentlicht in:International journal of biochemistry 1985, Vol.17 (2), p.187-193
Hauptverfasser: Ward, Leigh C., Carrington, Lyle E., Daly, Ross
Format: Artikel
Sprache:eng
Schlagworte:
Aminoisobutyric Acids - metabolism
Animals
Carbon Dioxide - analysis
Carbon Radioisotopes
Ethanol - blood
Ethanol - metabolism
Ethanol - pharmacology
Kinetics
Leucine - metabolism
Male
Oxidation-Reduction
Rats
Rats, Inbred Strains
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Zusammenfassung:1. 1. The effect of ethanol upon the oxidation of leucine by the rat in vivo was determined. 2. 2. The rate of leucine oxidation was not significantly altered by chronic administration of ethanol (20% v v solution as drinking water for 28 days). 3. 3. Ethanol administered acutely (8 g kg 0.73) significantly decreased leucine oxidation by the rat in vivo. This decrease appeared to be independent of a more general depression of oxidation metabolism. 4. 4. Decrease in leucine oxidation by ethanol is discussed in relation to the regulation of tissue leucine pool sizes in vivo.
ISSN:0020-711X
DOI:10.1016/0020-711X(85)90113-2