Acute leukemia characterized by trisomy 8 in down's syndrome

Acute leukemia characterized by trisomy 8 in down's syndrome

Of the myeloproliferative disorders which develop in Down's syndrome, acute leukemia associated with trisomy 8 has distinct characteristics. It is non-lymphoblastic in type and has a preleukemic phase in which thrombocytopenia is a prominent feature. One case occurring in a 20 mth-old girl is r...

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Veröffentlicht in:Pathology 1985, Vol.17 (1), p.111-114
Hauptverfasser: Broomhead, Alan F., Kwan, Y.L, Zell, N.A., Lam-Po-Tang, P.R.L., Hughes, D. O'Gorman
Format: Artikel
Sprache:eng
Schlagworte:
acute leukemia
Chromosomes, Human, 6-12 and X
Down Syndrome - complications
Down Syndrome - genetics
Down's syndrome
Female
Humans
Infant
Karyotyping
Leukemia - complications
Leukemia - genetics
preleukemia
thrombocytopenia
Trisomy
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Beschreibung
Zusammenfassung:Of the myeloproliferative disorders which develop in Down's syndrome, acute leukemia associated with trisomy 8 has distinct characteristics. It is non-lymphoblastic in type and has a preleukemic phase in which thrombocytopenia is a prominent feature. One case occurring in a 20 mth-old girl is reported and 3 other similar cases reviewed. Acquired trisomy 8 in Down's syndrome is linked to leukemogenesis and confers non-lymphoblastic differentiation
ISSN:0031-3025
1465-3931
DOI:10.3109/00313028509063737