The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

The p53 gene product is a tumor that is frequently inactivated during the development of cancer, and efforts to identify p53 target genes has revealed the mdm2, an oncogene originally found on mouse double minute chromosomes. The emergence of a p53-mdm2 regulatory loop has illuminated a circuit by w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioEssays 1993-10, Vol.15 (10), p.689-690
Hauptverfasser:	Picksley, S M, Lane, D P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cell Division - physiology Feedback Genetics Mice Neoplasm Proteins - physiology Nuclear Proteins Protein Binding Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 RNA - metabolism Tumor Suppressor Protein p53 - physiology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The p53 gene product is a tumor that is frequently inactivated during the development of cancer, and efforts to identify p53 target genes has revealed the mdm2, an oncogene originally found on mouse double minute chromosomes. The emergence of a p53-mdm2 regulatory loop has illuminated a circuit by which p53 might might control cell growth.
ISSN:	0265-9247 1521-1878
DOI:	10.1002/bies.950151008