Tiapamil - a new calcium antagonist
Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patient...
Gespeichert in:
| Veröffentlicht in: | South African medical journal 1985-06, Vol.67 (22), p.881-883 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 883 |
|---|---|
| container_issue | 22 |
| container_start_page | 881 |
| container_title | South African medical journal |
| container_volume | 67 |
| creator | Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G. |
| description | Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_JRA</sourceid><recordid>TN_cdi_proquest_miscellaneous_76137310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sabinet_id>10520/AJA20785135_5642</sabinet_id><sourcerecordid>76137310</sourcerecordid><originalsourceid>FETCH-LOGICAL-p243t-e5e6d06f19e1d2241446523bb256b123a8c8092e34755ba2a89e1105bd970f823</originalsourceid><addsrcrecordid>eNotkFtLxDAQhYMoa139CUJB8MlCMrm1j2XRVVnwZX0OkzaVSG82LeK_N8v2aTicjzkz54IkQHWeScblJUkoSJUVUotrchPCN41aFmpDNjwvKDCVkIejxxE736ZZimnvftMK28ovXYr9jF9D78N8S64abIO7W-eWfL48H3ev2eFj_7YrD9kIgs-Zk07VVDWscKwGEEwIJYFbG4-wDDjmVU4LcFxoKS0C5hFkVNq60LTJgW_J43nvOA0_iwuz6XyoXNti74YlGK0Y15zRCN6v4GI7V5tx8h1Of2b9KvpPZz-g9b2bTUAXURPDgJryvTx1dKrISCWA_wPuIFOp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76137310</pqid></control><display><type>article</type><title>Tiapamil - a new calcium antagonist</title><source>Sabinet Open Access Journals</source><creator>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</creator><creatorcontrib>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</creatorcontrib><description>Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent.</description><identifier>ISSN: 0256-9574</identifier><identifier>EISSN: 2078-5135</identifier><identifier>PMID: 3890216</identifier><language>eng</language><publisher>South Africa: Health and Medical Publishing Group (HMPG)</publisher><subject>Acute Disease ; Animals ; Anti-Arrhythmia Agents - therapeutic use ; Anti-arrhythmic effect ; Arrhythmias, Cardiac - drug therapy ; Calcium antagonist ; Calcium Channel Blockers - pharmacology ; Calcium Channel Blockers - therapeutic use ; Cardiology ; Chemical Phenomena ; Chemistry ; Clinical data ; Clinical Trials as Topic ; Clinical use ; Dogs ; Double-Blind Method ; Hemodynamics - drug effects ; Humans ; Kinetics ; Myocardial Infarction - drug therapy ; Pharmacology ; Propylamines - pharmacology ; Propylamines - therapeutic use ; Random Allocation ; Rats ; Swine ; Tiapamil ; Tiapamil Hydrochloride</subject><ispartof>South African medical journal, 1985-06, Vol.67 (22), p.881-883</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,39219</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/10520/AJA20785135_5642$$EView_record_in_Sabinet_Online_Ltd.$$FView_record_in_$$GSabinet_Online_Ltd.</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3890216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</creatorcontrib><title>Tiapamil - a new calcium antagonist</title><title>South African medical journal</title><addtitle>S Afr Med J</addtitle><description>Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Anti-arrhythmic effect</subject><subject>Arrhythmias, Cardiac - drug therapy</subject><subject>Calcium antagonist</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Cardiology</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Clinical data</subject><subject>Clinical Trials as Topic</subject><subject>Clinical use</subject><subject>Dogs</subject><subject>Double-Blind Method</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Pharmacology</subject><subject>Propylamines - pharmacology</subject><subject>Propylamines - therapeutic use</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Swine</subject><subject>Tiapamil</subject><subject>Tiapamil Hydrochloride</subject><issn>0256-9574</issn><issn>2078-5135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkFtLxDAQhYMoa139CUJB8MlCMrm1j2XRVVnwZX0OkzaVSG82LeK_N8v2aTicjzkz54IkQHWeScblJUkoSJUVUotrchPCN41aFmpDNjwvKDCVkIejxxE736ZZimnvftMK28ovXYr9jF9D78N8S64abIO7W-eWfL48H3ev2eFj_7YrD9kIgs-Zk07VVDWscKwGEEwIJYFbG4-wDDjmVU4LcFxoKS0C5hFkVNq60LTJgW_J43nvOA0_iwuz6XyoXNti74YlGK0Y15zRCN6v4GI7V5tx8h1Of2b9KvpPZz-g9b2bTUAXURPDgJryvTx1dKrISCWA_wPuIFOp</recordid><startdate>19850601</startdate><enddate>19850601</enddate><creator>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</creator><general>Health and Medical Publishing Group (HMPG)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19850601</creationdate><title>Tiapamil - a new calcium antagonist</title><author>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p243t-e5e6d06f19e1d2241446523bb256b123a8c8092e34755ba2a89e1105bd970f823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Anti-arrhythmic effect</topic><topic>Arrhythmias, Cardiac - drug therapy</topic><topic>Calcium antagonist</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Cardiology</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Clinical data</topic><topic>Clinical Trials as Topic</topic><topic>Clinical use</topic><topic>Dogs</topic><topic>Double-Blind Method</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Pharmacology</topic><topic>Propylamines - pharmacology</topic><topic>Propylamines - therapeutic use</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Swine</topic><topic>Tiapamil</topic><topic>Tiapamil Hydrochloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>South African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tiapamil - a new calcium antagonist</atitle><jtitle>South African medical journal</jtitle><addtitle>S Afr Med J</addtitle><date>1985-06-01</date><risdate>1985</risdate><volume>67</volume><issue>22</issue><spage>881</spage><epage>883</epage><pages>881-883</pages><issn>0256-9574</issn><eissn>2078-5135</eissn><abstract>Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent.</abstract><cop>South Africa</cop><pub>Health and Medical Publishing Group (HMPG)</pub><pmid>3890216</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0256-9574 |
| ispartof | South African medical journal, 1985-06, Vol.67 (22), p.881-883 |
| issn | 0256-9574 2078-5135 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76137310 |
| source | Sabinet Open Access Journals |
| subjects | Acute Disease Animals Anti-Arrhythmia Agents - therapeutic use Anti-arrhythmic effect Arrhythmias, Cardiac - drug therapy Calcium antagonist Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Cardiology Chemical Phenomena Chemistry Clinical data Clinical Trials as Topic Clinical use Dogs Double-Blind Method Hemodynamics - drug effects Humans Kinetics Myocardial Infarction - drug therapy Pharmacology Propylamines - pharmacology Propylamines - therapeutic use Random Allocation Rats Swine Tiapamil Tiapamil Hydrochloride |
| title | Tiapamil - a new calcium antagonist |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T01%3A37%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_JRA&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tiapamil%20-%20a%20new%20calcium%20antagonist&rft.jtitle=South%20African%20medical%20journal&rft.au=Opie,%20L.H.,%20Muller,%20C.A.,%20Thandroyen,%20F.T.,%20Lloyd,%20E.A.,%20Mabin,%20T.,%20Commerford,%20P.J.%20&%20Eichler,%20H.G.&rft.date=1985-06-01&rft.volume=67&rft.issue=22&rft.spage=881&rft.epage=883&rft.pages=881-883&rft.issn=0256-9574&rft.eissn=2078-5135&rft_id=info:doi/&rft_dat=%3Cproquest_JRA%3E76137310%3C/proquest_JRA%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76137310&rft_id=info:pmid/3890216&rft_sabinet_id=10520/AJA20785135_5642&rfr_iscdi=true |