Tiapamil - a new calcium antagonist

Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patient...

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Veröffentlicht in:	South African medical journal 1985-06, Vol.67 (22), p.881-883
1. Verfasser:	Opie, L.H., Muller, C.A., Thandroyen, F.T., Lloyd, E.A., Mabin, T., Commerford, P.J. & Eichler, H.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Anti-Arrhythmia Agents - therapeutic use Anti-arrhythmic effect Arrhythmias, Cardiac - drug therapy Calcium antagonist Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Cardiology Chemical Phenomena Chemistry Clinical data Clinical Trials as Topic Clinical use Dogs Double-Blind Method Hemodynamics - drug effects Humans Kinetics Myocardial Infarction - drug therapy Pharmacology Propylamines - pharmacology Propylamines - therapeutic use Random Allocation Rats Swine Tiapamil Tiapamil Hydrochloride
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Beschreibung
Zusammenfassung:	Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent.
ISSN:	0256-9574 2078-5135