Biphasic Liberation of Arachidonic and Stearic Acids During Cerebral Ischemia

: The mode of free fatty acid (FFA) liberation from the mouse brain during ischemia was investigated at various times after decapitation and under nizofenone treatment. Normal nonischemic brain FFAs consist mainly of palmitic acid (16:0), stearic acid (18:0), and oleic acid (18:1) with smaller amoun...

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Veröffentlicht in:	Journal of neurochemistry 1985-07, Vol.45 (1), p.168-172
Hauptverfasser:	Yasuda, Hiroshi, Kishiro, Kouji, Izumi, Noriyoshi, Nakanishi, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Arachidonic Acid Arachidonic Acids - metabolism ATP Biological and medical sciences Biphasic liberation Brain - drug effects Brain - metabolism Brain Ischemia - metabolism Cerebral ischemia Cyclic AMP - metabolism Fatty Acids, Nonesterified - metabolism Imidazoles - pharmacology In Vitro Techniques Kinetics Male Medical sciences Mice Nervous system involvement in other diseases. Miscellaneous Neurology Nizofenone Stearic acid Stearic Acids - metabolism
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Zusammenfassung:	: The mode of free fatty acid (FFA) liberation from the mouse brain during ischemia was investigated at various times after decapitation and under nizofenone treatment. Normal nonischemic brain FFAs consist mainly of palmitic acid (16:0), stearic acid (18:0), and oleic acid (18:1) with smaller amounts of arachidonic acid (20:4), docosahexaenoic acid (22:6), and others. Postde‐capitative ischemia induced a rapid, biphasic release of 20:4 after a short lag of
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.1985.tb05489.x