New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity

The new platinum(II) complexes of β-cyclodextrin functionalized at the primary position with ethylenediamine or with propylenediamine were synthesized and characterized by mass spectrometry, electronic spectrophotometry, and multinuclear NMR spectroscopy. Platinum(II) complexation makes the cavity m...

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Veröffentlicht in:	Journal of inorganic biochemistry 1993-11, Vol.52 (3), p.183-190
Hauptverfasser:	Cucinotta, Vincenzo, Mangano, Alfio, Nobile, Giuseppe, Santoro, Anna Maria, Vecchio, Graziella
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use beta-Cyclodextrins Biological and medical sciences Cyclodextrins - chemical synthesis Cyclodextrins - chemistry Cyclodextrins - therapeutic use DNA - metabolism General aspects Humans Lymphoma - drug therapy Magnetic Resonance Spectroscopy Medical sciences Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - therapeutic use Pharmacology. Drug treatments Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry Tumor Cells, Cultured
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Zusammenfassung:	The new platinum(II) complexes of β-cyclodextrin functionalized at the primary position with ethylenediamine or with propylenediamine were synthesized and characterized by mass spectrometry, electronic spectrophotometry, and multinuclear NMR spectroscopy. Platinum(II) complexation makes the cavity more asymmetric. These complexes were tested in vitro for their cytotoxic activity. The relevance of the low activity observed regarding the interaction between the cell and the cyclodextrin cavity is discussed.
ISSN:	0162-0134 1873-3344
DOI:	10.1016/0162-0134(93)80039-C