Biological activities of laminin

Laminin is a multifunctional protein with diverse biological activities. Like fibronectin, it can influence cell adhesion, growth, morphology, differentiation, migration, and agglutination as well as the assembly of the extracellular matrix. Laminin primarily affects cells of epithelial origin, and...

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Veröffentlicht in:	Journal of cellular biochemistry 1985, Vol.27 (4), p.317-325
Hauptverfasser:	Kleinman, Hynda K., Cannon, Frances B., Laurie, Gordon W., Hassell, John R., Aumailley, Monique, Terranova, Victor P., Martin, George R., DuBois-Dalcq, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basement membrane Basement Membrane - physiology Binding Sites Biological and medical sciences Cell Adhesion Cell coat. Cell surface Cell Differentiation Cell Division Cell Movement Cell structures and functions Cells - cytology Cells, Cultured Chemical Phenomena Chemistry Collagen - metabolism differentiation extracellular matrix Extracellular Matrix - physiology Fundamental and applied biological sciences. Psychology Hemagglutination Heparin - metabolism Heparitin Sulfate - metabolism laminin Laminin - physiology Macromolecular Substances Molecular and cellular biology Molecular Weight Neoplasm Metastasis Proteoglycans - metabolism reviews
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Beschreibung
Zusammenfassung:	Laminin is a multifunctional protein with diverse biological activities. Like fibronectin, it can influence cell adhesion, growth, morphology, differentiation, migration, and agglutination as well as the assembly of the extracellular matrix. Laminin primarily affects cells of epithelial origin, and the response varies depending on the cell. Because most differentiated cells are difficult to maintain in culture, laminin may be an important supplement in studies on cell differentiation in vitro.
ISSN:	0730-2312 1097-4644
DOI:	10.1002/jcb.240270402