A modified immunoperoxidase method for the detection of ABH tissue isoantigens in patients with bladder carcinoma

Detectable ABH blood group antigens (BGAg) on tumor cells from transitional carcinoma of the urinary bladder, used for diagnosis and prognosis may be evidenced with the existing immunoperoxidase methods. In this study, a modification of the immunoperoxidase method was shown to enable the detection o...

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Veröffentlicht in:	Experimental pathology (1981) 1985, Vol.27 (2), p.119-122
Hauptverfasser:	Stul, M.S., Logghe, G.N., Bergmans, G.B., Vanvuchelen, J.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABH tissue isoantigens ABO Blood-Group System - immunology carcinoma Carcinoma, Transitional Cell - immunology human Humans Immunoenzyme Techniques immunoperoxidase method Isoantigens - analysis urinary bladder Urinary Bladder - immunology Urinary Bladder Neoplasms - immunology urothelium
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Beschreibung
Zusammenfassung:	Detectable ABH blood group antigens (BGAg) on tumor cells from transitional carcinoma of the urinary bladder, used for diagnosis and prognosis may be evidenced with the existing immunoperoxidase methods. In this study, a modification of the immunoperoxidase method was shown to enable the detection of BGAg in deparaffinized tissue section of normal and malignant human urothelium. To detect antigens A and B a peroxidase-conjugated rabbit anti-human IgM was used and antigen H was visualized by biotinylated lectin.
ISSN:	0232-1513
DOI:	10.1016/S0232-1513(85)80049-9