Exogenous human surfactant for treatment of severe respiratory distress syndrome: A randomized prospective clinical trial

We performed a randomized, prospective clinical trial comparing intratracheal administration of human surfactant with conventional treatment with intermittent mandatory mechanical ventilation alone for treatment of severe respiratory distress syndrome in preterm infants of 30 days was significantly...

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Veröffentlicht in:	The Journal of pediatrics 1985-06, Vol.106 (6), p.963-969
Hauptverfasser:	Hallman, Mikko, Merritt, T. Allen, Jarvenpaa, Anna-Liisa, Boynton, Bruce, Mannino, Frank, Gluck, Louis, Moore, Thomas, Edwards, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic Fluid - analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Birth Weight Clinical Trials as Topic Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Humans Infant, Newborn Infant, Premature, Diseases - mortality Infant, Premature, Diseases - therapy Intensive care medicine Male Medical sciences Prospective Studies Random Allocation Respiratory Distress Syndrome, Newborn - mortality Respiratory Distress Syndrome, Newborn - therapy Surface-Active Agents - therapeutic use Time Factors
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Zusammenfassung:	We performed a randomized, prospective clinical trial comparing intratracheal administration of human surfactant with conventional treatment with intermittent mandatory mechanical ventilation alone for treatment of severe respiratory distress syndrome in preterm infants of 30 days was significantly less in the surfactant group. This trial confirms the efficacy of treatment with human surfactant in preterm infants with severe respiratory distress syndrome.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(85)80253-5