Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31

The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [ 111In]DTPA-MOC-31 showed good in vivo immunolocalisation to x...

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Veröffentlicht in:	European journal of cancer (1990) 1993, Vol.29 (13), p.1885-1890
Hauptverfasser:	de Jonge, Martinus W.A., Kosterink, Jos G.W., Bin, Yu Yan, Bulte, Jeff W.M., Kengen, Roland A.M., Piers, Do A., Hauw The, T., de Leij, Lou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Antibody Specificity Antigens, Surface - immunology Binding Sites, Antibody Carcinoma, Small Cell - diagnostic imaging Humans Indium Radioisotopes Lung Neoplasms - diagnostic imaging Male Middle Aged Radioimmunodetection Rats Rats, Nude Transplantation, Heterologous
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Zusammenfassung:	The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [ 111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.
ISSN:	0959-8049 1879-0852
DOI:	10.1016/0959-8049(93)90543-O