Liquid Chromatographic Determination of the Enantiomeric Composition of Amphetamine and Related Drugs by Diastereomeric Derivatization

A procedure is described for the derivatization of amphetamine and methamphetamine enantiomers with 4-nitrophenylsulfonyl-(S)-prolyl chloride. The resulting diastereomeric amphetamine derivatives were resolved by a reversed-phase procedure. The derivatization yield was maximized in the 95% range usi...

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Veröffentlicht in:	Journal of chromatographic science 1985-04, Vol.23 (4), p.176-180
Hauptverfasser:	Barksdale, Jeffrey M., Clark, C. Randall
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - analysis Analysis Applied sciences Biological and medical sciences Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Exact sciences and technology General pharmacology Indicators and Reagents Medical sciences Other techniques and industries Pharmacology. Drug treatments Solvents Stereoisomerism
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Zusammenfassung:	A procedure is described for the derivatization of amphetamine and methamphetamine enantiomers with 4-nitrophenylsulfonyl-(S)-prolyl chloride. The resulting diastereomeric amphetamine derivatives were resolved by a reversed-phase procedure. The derivatization yield was maximized in the 95% range using a five-fold molar excess of the chiral derivatizing agent and an approximate 18 to 1 ratio of base (NaHCO3) to total acid generated in the reaction.
ISSN:	0021-9665 1945-239X
DOI:	10.1093/chromsci/23.4.176