Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1

FK506-binding protein (FKBP) 12 and FKBP13 are members of a family of proteins which bind the immuno-suppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now re...

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Veröffentlicht in:	Gene 1993-12, Vol.134 (2), p.271-275
Hauptverfasser:	Hendrickson, Barbara A., Zhang, Wei, Craig, Robert J., Yong-Jiu, Jin, Bierer, Barbara E., Burakoff, Steven, DiLella, Anthony G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Blotting, Southern Carrier Proteins - genetics Cloning, Molecular Exons Fundamental and applied biological sciences. Psychology Genes. Genome genomic library Heat-Shock Proteins - genetics Humans immunophilin Immunosuppressant Introns Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data rapamycin recombinant DNA Sequence Homology, Amino Acid Tacrolimus Tacrolimus Binding Proteins
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Zusammenfassung:	FK506-binding protein (FKBP) 12 and FKBP13 are members of a family of proteins which bind the immuno-suppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/0378-1119(93)90106-D