CHLOROCARDICIN, A MONOCYCLIC β-LACTAM FROM A STREPTOMYCES SP: II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

CHLOROCARDICIN, A MONOCYCLIC β-LACTAM FROM A STREPTOMYCES SP: II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

Chlorocardicin, a novel monocyclic β-lactam, was isolated from the fermentation broth of a Streptomyces sp. by the use of non-ionic porous resin and reverse phase chromatography. This chlorine-containing antibiotic is structurally related to nocardicin A. Its physico-chemical characteristics and det...

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Veröffentlicht in:Journal of antibiotics 1985, Vol.38(2), pp.139-144
Hauptverfasser: CHAN, JAMES A., SHULTIS, ELVA A., DINGERDISSEN, JOHN J., DEBROSSE, CHARLES W., ROBERTS, GERALD D., SNADER, KENNETH M.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - isolation & purification
beta-Lactams
Biological and medical sciences
Chemical Phenomena
Chemistry
Chromatography - methods
General pharmacology
Lactams
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Spectrophotometry, Ultraviolet
Streptomyces
Streptomyces - analysis
Streptomyces - metabolism
Structure-Activity Relationship
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Zusammenfassung:Chlorocardicin, a novel monocyclic β-lactam, was isolated from the fermentation broth of a Streptomyces sp. by the use of non-ionic porous resin and reverse phase chromatography. This chlorine-containing antibiotic is structurally related to nocardicin A. Its physico-chemical characteristics and detailed NMR analysis are described.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.139